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NO exerts profound effects on CRC through angiogenesis, immunomodulation, and ferroptosis, with therapeutic strategies targeting NOS coupling, EV-mediated pathways, and ferroptosis induction showing significant promise

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Concern has been raised that rhGH may stimulate the immune system in KTx patients and thereby promote acute rejection episodes with the consequence of poor graft outcome in children

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Ndufs2 KO adipocytes showed reduced expression of the pathways involved in fatty acid metabolism, insulin signalling, peroxisome proliferator-activated receptor (PPAR) signalling and lipolysis, along with activation of oxidative stress, inflammatory and glycolytic programmes